The COBRE Center for Stem Cells and Aging grant has four projects dealing with stem cells and various aspects of aging, fibrosis and cellular senescence. The projects focus on hematopoietic stem cells, their microenvironment and the impact of aging on the fibrotic component of that microenvironment, neural stem cells, and their regulation with aging.
The renewal of our grant allows Lifespan and Rhode Island Hospital to update research infrastructure for expanded studies into normal and malignant stem cells. In turn, these upgrades in infrastructure will enhance Lifespan’s focus on establishing a comprehensive cancer and stem cell program that will foster the development of novel treatment strategies, conduct nationally recognized research efforts, and devise effective methods of cancer prevention
Promising applications for our research include regeneration and repair for the treatment of leukemia, lymphomas, various neurodegenerative disorders, and different aspects of aging.
We treat all orthopedic injuries and diseases for patients of all ages and activity levels with advanced orthopedic techniques and technologies and an uncommon caring touch. It’s comprehensive musculoskeletal care that helps eliminate pain and brings our patients back to their version of normal.
Oral & Maxillofacial Surgeon, Robert S. Gilardetti, D.M.D., M.D. , Wakefield, Rhode Island, practices a full scope of oral and maxillofacial surgery with expertise ranging from corrective jaw surgery to wisdom tooth removal. We can also diagnose and treat facial pain, facial injuries, and TMJ disorders, and perform a full range of dental implant and bone grafting procedures.
Dr. Gilardetti’s staff is trained in assisting with I.V. sedation within our state of the art office setting.
Roy Kenneth Aaron, M.D., a specialist in arthritis and metabolic bone disease, is an attending orthopedic surgeon at Miriam Hospital. He is the Director of clinical research for the department and Director of the Orthopaedic Cell Biology Laboratory. He is also Director of the Brown / VA Center for Restorative and Regenerative Medicine.
Dr. Aaron performs arthroscopic and other procedures for joint preservation in arthritis. Dr. Aaron spends a substantial amount of time in the laboratory and is doing research into osteoarthritis and cartilage transplantation using stem cells for joint resurfacing. He is interested in the use of biological alternatives to joint replacements for joint diseases.