New York
PARK AVENUE STEM CELL THERAPY
Stem Cell Therapy is part of an exciting new field in medicine called Regenerative Medicine. In traditional medical treatment, we rely on NSAIDs, Steroids, other pharmaceuticals or surgery. At Park Avenue Stem Cell as part of the Cell Surgical Network(CSN), we are investigating the use of stromal vascular fraction(SVF) containing Adipose-Derived Stem Cells in the mitigation of cellular degenerative conditions such as chronic inflammation, arthritis, COPD, Alzheimer’s Disease and many other conditions. This research is part of an FDA approved preliminary safety study an IRB numbers ICSS-2016-001 though ICSS-2016-21, and we have maintained an extensive database that now includes more than 5000 patients. Please refer to “A Prospective Safety Study of Autologous Adipose-Derived Stromal Vascular Fraction Using a Specialized Surgical Processing System” by Mark Berman, M.D. and Elliot Lander, M.D., Am. J Cosmetic Surgery, 2017 for additional information.
PARK AVENUE STEM CELL OVERVIEW
#1 STEM CELL AUTHORITY
Dr. Joel Singer, a board-certified plastic surgeon, leverages over 30 years of extensive medical experience in his practices in New York City and Greenwich CT. Possessing a particular interest in nonsurgical and minimally invasive procedures, Dr. Joel Singer incorporates the latest techniques into his repertoire of services.
Dr. Singer began his formal education as an undergraduate at Queens College, The City University of New York. Committed to academic excellence, he was accepted into medical school after his second year of studying chemistry and biology. Dr. Singer earned his Doctor of Medicine from the Yale School of Medicine. He subsequently completed residencies at Yale-New Haven Medical Center and Rhode Island Brown University Hospital. He returned to academia in 2007, earning his M.B.A. from the George Washington University School of Business.
Dr. Singer has always been at the leading edge of innovation was the first plastic surgeon in Connecticut to perform liposuction in the early 1980s. His interest in fat transfer lead him to his current interest in investigating the benefits of autologous fat-derived Adult Stem Cells. He was an early affiliate in the Cell Surgical Network® an international organization of physicians devoted to clinical research of the benefits of adipose-derived stem cells.
He has built a physician network of multiple specialists who have been collaborating with Park Avenue Stem Cell to help treat chronic conditions in their patients. Dr. Singer is passionate about his research into the clinical applications of Stem Cells and has helped numerous people to be free of pain and chronic symptoms. Dr. Joel Singer has traveled around the globe to provide training to local plastic surgeons, as well as free surgeries to children in need. Dr. Joel Singer continues his involvement in the medical community through active participation in various medical organizations at both national and local levels, including the American Society of Plastic Surgeons and the New England Society of Plastic Surgeons.
Who is Dr. Soni
Named #1 Obesity Doctor in NY
Named America’s Top Physician 3 years in a row
Named Top Sleep Doctor in America 3 years in a row
Has 8 American Board Certifications
Using Knowledge of 8 Specialities for one aim: Weight Loss
Using knowledge of 8 specialties to find the root of the problems and not just treat the symptoms.
Our team is unique because
Dr. Soni is a board-certified physician in 8 different medical specialties
Over 25 years of experience
Most insurance plans are accepted
We offer a wide range of non-surgical options
Lipoplasty (liposuction) offered as a surgical option for abdominal (belly) fat removal
Medically supervised weight loss programs feature a 99% success rate
Weight loss programs covered by most insurance plans
Offer treatment for hormone imbalances and sexual disorders
Offer stem cell and PRP treatments
Specializes in sleep disorders
Comprehensive anti-aging treatments available
About our Practice
Liondale Medical is a private practice that focuses on the individualized care of our patients. We believe the best care comes from time spent listening to our patients. Dr. Bissoon sees a limited number of patients each day in order to ensure the quality of care we provide. Liondale Medical is committed to offering our patients personalized and comprehensive health care they want and deserve.
Dr. Lionel Bissoon
Dr. Lionel Bissoon; our medical director, has a background in Physical Medicine & Rehabilitation, Hormone Replacement Therapy, Cosmetic Dermatology and specializes in Regenerative and Restorative Medicine.
Dr. Bissoon is one of just a handful of doctors in the country who is employing the natural regenerative benefits of stem cells as an alternative to highly invasive joint replacement surgeries for patients with acute and chronic pain in their knees, shoulders, wrists, ankles, hands, feet, hips, elbows and certain spinal conditions. In addition, because stem cells can convert to from many tissues such as bone, cartilage, ligament, tendons, muscle or fat, they also can be used to treat debilitating conditions, such as degenerative arthritis, rheumatoid arthritis or osteoarthritis.
Dr. Bissoon has a well-known history of integrating new and innovative technology into the practice of medicine. In the late 1990’s he introduced Mesotherapy for the treatment of cellulite and weight loss. This procedure brought him numerous television, newspaper, and national magazine interviews.
Quality Medicine & Personally Tailored Programs
The use of a person’s own stem cells to heal themselves is a unique approach to treating Orthopedic, musculoskeletal and degenerative changes from arthritis. We are happy to offer this treatment to our patients who do not want to have surgery, improve their function and be pain-free.
Specializing in Regenerative Medicine
Liondale Medical continues to be at the forefront of cutting edge medical technology.
The use of stem cell therapy for joint injuries has been proven in most cases to eliminate the need for invasive reconstructive surgery, pain medications and improve function for people with joint and cartilage injuries.
The human body naturally contains millions of adult stem cells which are found in our fat, bones and other tissues. Adult stem cells can be harvested either from the patient’s, fat or bone marrow through a quick and relatively pain-free procedure. The stem cells are collected and injected within 30-60 minutes of the harvest into the site of the injury. The process of harvesting fat stem cells and bone stem cells are both FDA approved.
Adult stem cells are highly regenerative and have the ability to restore and repair injured tissue and joints, therefore, eliminating the need for invasive surgical procedures. Thus, there is no need to suffer needlessly, undergo invasive surgery, and take long term pain medications and non-steroidal medications if you are a candidate for the autologous stem cell treatment.
Is This Legal?
Yes! Currently, the FDA does not allow for manipulation and growing of stem cells; basically it is illegal. However, it is legal to administer the stem cells from fat and bone on the day of harvest. Plastic and Orthopedic surgeons have been using fat and bone marrow injections for decades. In summary, if stem cells are to be harvested from a person for medical purposes, they must be replanted in that person the same day without any cultivation or expansion.
STEM CELL SCIENCES, INC. (SCS) is a privately owned, NYSDOH licensed comprehensive stem cell bank, registered with the FDA and approved for the procurement, processing, storage, and distribution of human hematopoietic (blood-forming) stem cells of bone marrow and peripheral blood origin. Stem cells collected and processed by us have been successfully used since 1993 for the engraftment of many patients with a diagnosis of cancer (Acute and Chronic Leukemia, Lymphomas, both Hodgkin’s and Non-Hodgkin’s, Multiple Myeloma, Breast Cancer and other solid tumors) that were treated at several premier New York Hospitals.
In addition to its activity related to established therapeutic usage of hematopoietic stem cells for the treatment of cancer, the company is also engaged in bench research of marrow-derived mesenchymal (stromal/non-blood forming) stem cells for future clinical applications in the treatment of joint diseases as well as inflammatory bowel diseases and certain auto-immune disorders.
SCS facility is located in midtown Manhattan with an available space of approx. 3000 sq. ft. comprising an apheresis suite for peripheral blood stem cell collections, a stem cell laboratory, medical offices and examination rooms properly equipped to allow bone marrow aspiration sampling.
The stem cell laboratory hosts the necessary equipment for the large scale processing of stem cells under sterile conditions, short and long term in-vitro culture of stem cells, liquid nitrogen storage as well as microscopy and PCR capabilities for research purposes.
SCS intends to continue its excellence in banking hematopoietic stem cells for the treatment of certain cancers and to establish itself as a facility dedicated to advance marrow-derived stromal stem cell research in preparation for clinical applications.
Therapeutic usage of hematopoietic stem cells:
Transplantation of bone marrow and/or peripheral blood stem cells is currently used in conjunction with high dose chemotherapy for the intended curative treatment of certain blood disorders that include: Acute Myelogenous Leukemia (AML), Acute Lymphoblastic Leukemia (ALL), Chronic Myelogenous Leukemia (CML), Chronic Lymphocytic Leukemia (CLL), Hodgkin’s Disease (HD), several types of Non-Hodgkin’s Lymphoma (NHL) including Mantle Cell Lymphoma (MCL) and Multiple Myeloma (MM).
Transplantation for solid tumors is now considered experimental.
When the patient’s own stem cells are used, the transplant is called autologous and when a relative’s or unrelated donor’s stem cells are used, the procedure is called allogeneic transplantation. The latter is associated also with an immune component called graft-versus host disease that may have possible benefits for disease control, but may also cause complications leading to increased morbidity and mortality.
Adequate quality of stem cells is of paramount importance and is measured in both cell number content and presence of CD34 positive cells administered per kilogram body weight, in addition with proof that there is no bacterial, fungal or viral contamination of collections. Stem cell donors undergo a rigorous screening process including a detailed confidential questionnaire and blood testing for a variety of diseases.
We maintain stem cell collections for clinical use in liquid nitrogen storage.
2. Therapeutic usage of marrow-derived mesenchymal (stromal) stem cells:
These procedures are not yet in the main stream of practice of medicine, but rapid developments indicate that soon they may become a clinical reality in the United States. As such, transplantation of mesenchymal (stromal) stem cells is performed only under closely monitored clinical trials with FDA approval. The reason for such monitoring is due to the fact that several weeks of in-vitro culture are necessary to procure an adequate number of mesenchymal (stromal) stem cells and demonstration of mesenchymal (stromal) cells’ ability to differentiate into other types of cells (like cartilage or bone-forming) is necessary.
Under clinical trials (performed so far mainly overseas) mesenchymal (stromal) stem cells were found to be successful for the treatment of cartilage and bone defects associated with osteoarthritis and rheumatoid arthritis as well as in Inflammatory Bowel Diseases like Crohn’s Disease and Ulcerative Colitis or immune-related conditions like Graft-versus-Host Disease and Multiple Sclerosis.
Dr. Leon Reyfman and his team of pain management and relief specialists have always believed that the least invasive tactics for relieving pain are the most beneficial. When you visit Dr. Reyfman in his Brooklyn NYC office, you’re treated with respect and concern. If you’re in pain, it’s Dr. Leon Reyfman’s job to relieve it.
This therapy is widely becoming recognized and accepted throughout the traditional medical community as the first line of defense against chronic pain. Stem cell treatments rely on your own stem cells — removed from your bone marrow or adipose fat tissue and injected into the areas that are causing you pain. There’s no need to tread into the controversial field of embryonic stem cell cultivation when you carry all the necessary tools within your own body to heal yourself. When you visit the Brooklyn office, you never receive cookie-cutter treatment. Following a thorough medical history and a complete examination that may include blood work and X-rays, Dr. Leon Reyfman spends time getting to know you, your medical goals and your willingness to try innovative procedures, such as stem cell therapy.
Pain Is Not Your Friend
Chances are, you’re visiting an interventional pain management specialist because traditional means of treating your condition haven’t produced the results you want. To maintain your busy Brooklyn lifestyle, you can’t be slowed by degenerative conditions such as:
Shoulder arthritis
Tendonitis
Chronic neck pain
Chronic back pain
Hip arthritis
Arthritis in your knee or ankle
These conditions often require you to undergo extensive replacement surgery that comes with lengthy recovery times. Even then, you still may have to deal with lingering pain. Surgery is sometimes the only answer, but it should be the very last option.
Accidents Happen
Injuries from athletics, accidents or persistent wear and tear can lead to other conditions that very often leave you feeling like you’re stuck with chronic pain for the rest of your life. These conditions include:
Tennis elbow
Meniscus tear
Rotator cuff tear
Hip injuries
Knee injuries
Foot and ankle injuries
Hand and wrist injuries
Natural Relief Is Available
As an interventional pain management specialist with years of experience in NYC, Dr. Leon Reyfman and his team have relied on traditional methods of pain management. But now they offer stem cell therapy treatment and regenerative therapy for all of the above-mentioned conditions … and more!
Additionally, platelet-rich plasma treatments rely on your own healthy blood cells to stir the recovery of diseased and damaged areas of your body. A simple centrifuge spins platelets out of your blood so that they can be injected directly into the places that need a greater blood supply.
Dr. Leon Reyfman’s Credentials
In the past, you may have been offered “alternative” or “natural” treatments from medical practitioners who practiced outside of mainstream medicine. That’s no longer true, as Dr. Leon Reyfman, MD, RPh, is both a medical doctor and a registered pharmacist. His credentials include:
Ross University Medical School’s prestigious Award of Academic Excellence
Internship in Internal Medicine at Maimonides Medical Center
Residency in Anesthesiology with focus on Pain Medicine at SUNY Downstate Medical Center in Brooklyn, NY
Fellowship at the world-renowned Columbia University College of Physicians and Surgeons/St. Luke’s Roosevelt Hospital
Board-certified through the American Board of Anesthesiology in both Anesthesiology and Pain Management
Dr. Leon Reyfman has extensive clinical experience and training in invasive and non-invasive pain management. He currently serves as the Director of Interventional Pain Medicine, and he is an Assistant Clinical Professor of Anesthesiology at SUNY Downstate Medical School. Dr. Reyfman is a member of the American Society of Interventional Pain Physicians and the International Spine Intervention Society.
Looking Out for Your Best Interests
Dr. Leon Reyfman is actively involved in pain management research; he’s seen first-hand the profound benefits that stem cell therapy has had on patients around the world. You may only need one or two visits before you begin to feel incredible relief from the debilitating pain you thought would never leave.
Thanks to his efforts and willingness to invest in the necessary technology, Dr. Reyfman, and his colleagues can provide you with access to life-altering treatments, such as:
Stem cell therapy for backs that can target disc degeneration, lumbar issues, bulging discs, herniated discs and more.
Stem cell therapy for shoulders, ideal for treating shoulder injuries, torn ligaments, osteoarthritis in the shoulder and rotator cuff injuries.
Stem cell therapy instead of knee replacement, a boon to seniors who face risky replacement surgery just to remain mobile.
Stem cell therapy for hips, another treatment that can eliminate the need for replacement surgery and painful physical therapy.
Regenerative Therapies Now Available
Instead of relying on addictive pain medications, steroid injections and risky surgery, talk to Dr. Leon Reyfman about whether you’re eligible for stem cell treatments and other regenerative therapies. While your age and general health come into play in the determination, you don’t have to worry about:
The risks of rejection, since the stem cells come from your own body
The medical expertise of your doctor, since Dr. Leon Reyfman has the training and experience
Through his numerous appointments and participation in cutting-edge research organizations, Dr. Reyfman stays abreast of the news. He’s an active member of many professional organizations, including:
American Medical Association (AMA), 2002–present
American Society of Anesthesiology (ASA), 2003–present
NY State Society of Anesthesiology (NYSSA), 2003–present
American Society of Regional Anesthesia and Pain Medicine (ASRA), 2005–present
American Society of Interventional Pain Physicians (ASIPP), 2007–present
International Spine Intervention Society (ISIS), 2007–present
North American Spine Society (NASS), 2011–present
The New York Pain Society, 2011-present — founding member
American Society of Addiction Medicine, 2010–present
The Medical Society of the State of New York, 2004–present
International Society of Medical Laser Application, 2013–present
His many licensures and certifications include:
Physician and Surgeon Licensed by the New York and New Jersey Medical Board
Board Certified by American Board of Anesthesiology
Diplomate of the American Board of Anesthesiology and Pain Medicine
Board Certified by American Board of Independent Medical Examiners
Fellow of Interventional Pain Practice
Stem Cell Therapy is a therapy program where people can get various diseases treatment by their therapies
Stem Cell Therapy follows the same procedure as traditional stem cell therapy, but we provide therapies in much less cost, less risk, yet similar or more efficiency. Stem Cell Therapy started their work with a selection of specific organ cells from an animal fetus. Those animal fetuses are bred specifically for this purpose. Our researchers trying their best to give some quality therapy treatment for specific disease affected people. Many years of research, studies, and experience have proven that sheep are the best donor animals. They are essential and hardy animals with perhaps the strongest resistant systems and natural disease resistance. Sheep proteins are particularly compatible with the human body.
Stem Cell Therapies are associated with a capsule method therapy for all types of diseases
We don’t follow any surgery. Our therapies are appropriate to reduce the complications of the person to improve their daily life. In the case of many other organic medicines, this kind of solution is free of proteins in addition to unnatural human hormones, which commonly change the regular hormone creation. Our therapies increase the energy level of the person as well as the strength of the person. Usually, our capsule therapy works with fresh cells of the body. It recreates new cells along with fresh cells. It stimulates the nerve cells and also enhances the beauty of your face too.
Stem Cell Therapy tries to give their best to their patient to cure or improve their condition from the complications
In the case of some diseases, which are not curable, our therapy will help you to improve your situation. Our therapies reduce joint pain, body aches, etc. Since stem cells have no antigens, they are not identified as the foreign element by the host body. We believe that our treatment will be beneficial for all types of disease affected people to help their condition. Our therapy also helps the person to improve their memory. Therapies also prevent inflammation in the human body. It will also prevent some other complications of the people. It improves the condition of people who have a feeling of shortness of breathing.
We are offering you to start your treatment with Stem Cells Therapy for your specific disease, which has no side effects
But if you complete the full frame of treatment you are going to be settled down progressively. It will improve your complications and you will get stress free night.
Disclaimer: The statements on this website are based on anecdotal evidence and have not been evaluated by the FDA. All supplements are not drugs and are not to be claimed as a cure for a disease or injury. The information appearing on this website is not intended to be a substitute for professional medical advice. Results may vary between individuals. – For more information contact us.
The StemSave Advantage
Choosing to bank your stem cells is an important decision for your family’s future health. Our mission is to make the benefits of regenerative medicine and stem cell science accessible, convenient and affordable for you and your family. StemSave’s patented technology, fully accredited lab facilities, stem cell processing expertise, and world-class Scientific Advisory Council are why more families and dentists choose to bank their stem cells with StemSave. As the industry leader, StemSave is the only stem cell banking service to be designated as an ASI Approved Program.
Stem Cell Overview
StemSave™ stem cell banking offers you and your family a unique stem cell recovery and cryopreservation service, in the event of future injury or disease.
The restorative properties of stem cells:
Stem cells are unique because they drive the natural healing process throughout your life. Stem cells are different from other cells in the body because they regenerate and produce specialized cell types. They heal and restore skin, bones, cartilage, muscles, nerves and other tissues when injured. There are two main types of stem cells: adult stem cells, such as those found in bone marrow and teeth (see Stem Cells in Teeth), and embryonic stem cells (see Other Stem Cells).
Today, medical researchers are learning how to control stem cells and direct their growth into specialized cells, including blood, skin, bone, cartilage, teeth, muscle and nerves.
As a result, amazing new medical treatments are being developed to treat a range of diseases contemporary medicine currently deems difficult or impossible to treat. Among them are:
Parkinson’s Disease
Brain Injuries
Heart Disease
Diabetes
Arthritis
Muscular dystrophy
Leukemia
Crohn’s disease
Multiple Sclerosis
Neimann-Pick Type C
Periodontal Disease
Sports Injuries
Cosmetic and Anti-aging applications to date, over 6000 clinical trials have been conducted and over 70 clinical applications utilizing Adult Stem Cells have been approved.
2 Easy Steps
StemSave is a collaboration of Dentists and stem cell researchers who want to give families a convenient and reliable way to benefit from emerging new healthcare treatments.
By enrolling in our program, you and your Dentist can preserve your family’s vital stem cells in the event of future disease or injury.
Like “biological insurance,” storing Dental Stem Cells gives you and your family the option to choose the most advanced medical treatments available in the years ahead, when you may need them most.
Best of all, StemSave makes this option simple and affordable in two easy steps.
When your child’s baby tooth becomes loose, or when a dental professional recommends that you or a family member has a tooth or wisdom teeth removed, this is your opportunity to secure stem cells through StemSave.
All you have to do is follow the 2 Easy Steps:
STEP 1: Enroll in StemSave. Your personalized StemSave recovery and transport kit, along with an email notification, will be sent directly to your Dentist. If your Dentist is not already enrolled as StemSave Dental Professional, we will contact him or her directly to introduce ourselves and navigate them through our easy Dental Professional enrollment page. Contact us to see if your Dentist is a StemSave provider.
STEP 2: Make an appointment with your Dentist for the planned procedure and the convenient recovery of your stem cells.
Securing your stem cells is easy – How your dentist does it:
The loose baby tooth, extracted permanent tooth or wisdom teeth are recovered by your dentist at the time of the planned dental procedure.
StemSave’s patented recovery and transport system protects and nourishes the stem cells while the tooth is rushed to our laboratory.
StemSave’s laboratory removes the cells from inside the teeth and assesses whether the cells are viable prior to cryopreservation. Cells that are not viable will not be stored.
The cells are cryogenically-preserved using state-of-the-art technology and securely stored and monitored until needed.
Verifying storage and keeping your family’s records:
Our lab will notify you and your Dentist when the stem cells are securely stored, and provide you with contact information that you should keep with your family’s medical records for future use.
The Helen L. and Martin S. Kimmel Center for Stem Cell Biology was established in 2005 with a mission to be at the forefront of stem cell biology research. The goal is to conduct high caliber stem cell research that can ultimately lead to medical advances. We have over 40 faculty members, all of whom work on a variety of areas within stem cell biology. Members are affiliated with more than 20 different departments and institutions at the NYU Langone Medical Center, representative of the multidisciplinary nature of the center. The Kimmel Center for Stem Cell Biology faculty are internationally renowned and have received many honors and awards. Faculty include members of the National Academy of Sciences and Howard Hughes Medical Investigators.
Research at the center is focused on four broad areas, including (1) programming and reprogramming, lineage restriction and development, (2) tissue stem cells and disease, (3) regeneration and homeostasis, and (4) cancer and stem cells. Scientists within the center focus on one or more of the research areas and conduct their studies on a variety of tissue/organ systems ranging from embryonic stem cells to brain, heart, bone, lung and many more tissue systems in between.
The Stem Cell Biology training program in The Sackler Institute of Graduate Biomedical Sciences is designed to promote interdisciplinary studies within the field of stem cell biology for graduate students and postdoctoral fellows. We provide a great environment for trainees to explore the vast field of stem cell biology research. In addition to having a choice of mentors that range in their disciplines within stem cell biology, trainees are offered a seminar series, stem cell biology course, and stem cell biology tutorials, aimed at providing trainees with a breadth of knowledge in the field of stem cell biology. Our location in New York City also provides the opportunity for attendance at many local conferences and seminars within a short radius of the school.
The mission of the Helen L. and Martin S. Kimmel Center for Stem Cell Biology is to establish a world-class, multidisciplinary research center focusing on the basic biology of stem cells in a variety of species and cell types. Every day we are making strides towards achieving this goal!
The mission of The New York Stem Cell Foundation is to cure the major diseases of our time through stem cell research.
In addition to conducting innovative stem cell research in our own safe haven laboratories, NYSCF also supports and convenes global stem cell thought leaders and the broader stem cell community – all with the focus on getting to patients. Since our founding in 2005, NYSCF has been able to achieve outsized results in a relatively short period of time thanks to private philanthropy.
The NYSCF Research Institute, an independent laboratory, is a non-profit accelerator that serves to bridge the ongoing gap between research institutions and pharmaceutical and biotech companies by reducing the cost, time, and risk that historically inhibit the development of new treatments and cures. In just over one decade, NYSCF has created not only foundational tools for using stem cells in basic research but also pioneering technologies that will allow stem cells to be used therapeutically.
By pursuing and supporting only the most promising stem cell research and technologies, in our own laboratories and in partnership with leading institutions around the world, NYSCF serves as a catalyst in this transformational field, advancing our mission to accelerate cures for the major diseases of our time.
Accelerating cures for the major diseases of our time through stem cell research.
OUR MISSION & IMPACT
The New York Stem Cell Foundation combines the depth of a highly focused research institute with the breadth of a wide-ranging philanthropic organization. Since its establishment in 2005, NYSCF has invested over $200 million in stem cell research and continues to conduct the most advanced stem cell research internationally, both in its own laboratory in New York City and also in collaboration with major medical research and leading academic institutions around the world.
The Mission of Tisch MS Research Center of New York
The Tisch MS Research Center of New York is an independent nonprofit 501(c)(3) organization dedicated to finding the cause and a cure for multiple sclerosis by conducting groundbreaking medical research to accelerate the pace at which research discoveries translate from lab bench to bedside. The Center aims to identify the cause of MS, understand disease mechanism, optimize therapies, and repair the damage caused by MS while offering patient access to the best and most advanced treatment possible. The Center’s medical research is designed to understand all aspects of MS, including research at the cellular and molecular levels, in order to treat and cure MS. Our stem cell studies are the most exciting of all of our research projects. The Neural Cell Regeneration and Repair study is working to perfect a treatment using the patient’s own adult stem cells to regenerate and repair nerve cells and help patients recover lost functions. We are committed to our mission and invite you to explore our website and learn more about our research activities, facilities, scientific and educational events.
Our MS Research
At Tisch MS we have several ongoing research projects. All investigations happening in the Tisch MS Research laboratory focus on learning more about this chronic disease and ways to end it or repair the damage it has caused. Browse this section to learn more about each project.
Our areas of interest include:
STEM CELL PROGRAM/REGENERATIVE REPAIR
Our Phase I clinical trial is the only clinical trial of its kind in the United States to test freshly harvested MSC-NP cells administered intrathecally in multiple dosing regimens. Results showed dosing was well tolerated with only minor adverse events, and 15 of 20 subjects demonstrated functional neurological improvement. To make MSC-NPs, autologous stem cells are taken from a patient’s own bone marrow. These are called mesenchymal stem cells (MSCs). The MSCs expanded from the bone marrow are then manipulated in the laboratory to make them into neural progenitor cells, which are MSC-NPs. Our Phase II randomized placebo-controlled study will test the efficacy of intrathecal MSC-NP treatment in patients with progressive MS. This will be a double-blind study of 50 patients, all of whom will eventually receive treatment with MSC-NPs. Construction of the Tisch MS Center’s, Regenerative Medicine Laboratory began in the summer of 2017, and it is expected to open winter of 2018. Upon completion of the build-out, we plan to begin enrollment of our Phase II Study.
UNDERSTAND DISEASE PROGRESSION
A major focus of research at Tisch MS is to investigate the underlying causes of disease progression using novel approaches based on comparative analysis of cerebrospinal fluid (CSF). Our emphasis is on identifying possible therapeutic targets for and novel biomarkers of disease activity in progressive MS patients. To accomplish this, we are studying changes in metabolism, the function of astrocytes, and the role of intrathecal delivery of methotrexate (IT-MTX) in this population. Additionally, we are developing a novel animal model to further understand the trajectory of progressive MS.
DISCOVER THE CAUSE OF MS
To discover the cause of MS, our researchers are looking into what B-cells in the immune system is attacking. We are attempting to answer questions such as if there is a particular protein in myelin that’s attacked? Is EBV involved in MS? Can we find the trigger of MS, if there is one? It is our hope that looking at MS B-cells and the antibodies they produce, will answer some of these questions and ultimately lead us to the cause of the disease.
TRANSLATE THE RESEARCH TO PATIENTS
Biomarkers are specific and sensitive assays that help in better diagnosis, assessment of disease activity, and measurement of treatment responses. Using CSF analysis, we can determine how active the disease is (Fetuin A level), how likely is it to progress (osteopontin), and the level of oxidative stress (lipid peroxidation levels). Together with single B-cell analysis, for even the most complex patient cases, we can rationally decide on which treatment is most likely to be effective and how potent or aggressive therapy is needed.